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by partners or was simply lacking Oracle Database 10 g Enterprise Edition was introduced in 2003 with Automatic Storage Management (ASM) and embedded cluster management software, eliminating the need for thirdparty software that provided those capabilities ASM virtualizes storage resources and provides advanced volume management, thus enabling the database and DBA to manage tasks such as striping and mirroring of data The Automatic Database Diagnostics Monitor (ADDM) also first appeared in this release and provided advisory alerts and suggestions for tactics to improve performance based on periodic snapshots of performance in a production environment These suggestions are displayed to DBAs by Enterprise Manager s Grid Control, whose enhanced alerting and management capabilities are critically important when deploying Oracle for large-scale databases and for grid computing In 2005, penguins appeared on stage at Oracle OpenWorld in what was seen as a curious announcement at the time but would have important implications in establishing a complete Oracle platform Oracle announced it would provide support for Red Hat and SUSE Linux and deliver an unbreakable Linux support model Oracle later introduced Oracle Enterprise Linux, which has roots in Red Hat Linux from the open-source community to which Oracle had long provided technology Meanwhile, Oracle had begun work on establishing reference configurations for data warehousing on Linuxbased and other platforms from a variety of platform vendors Taken together, these moves by Oracle and the changes in the deployment strategies at many of Oracle customers led to Oracle s decision to launch a tightly integrated hardware and software platform The initial platform, the HP Oracle Database Machine with Exadata storage, became available in 2008 In 2009, Oracle announced a second generation of the Oracle Exadata Database Machine and a new hardware platform the Sun Oracle Database Machine The acquisition of Sun by Oracle Corporation in 2010 completed the transition of Oracle to a vendor that can design, build, and support complete database hardware and software solutions that are deployed as systems In September 2010, Oracle announced new X2-2 and X2-8 nodes for the Oracle Exadata Database Machine and also announced Solaris 11 as an alternative to the Oracle Enterprise Linux operating system for database server nodes The Unbreakable Enterprise Kernel for Linux was announced at this time to provide support for the large number of processing cores made available in the Exadata Database Machine We ll discuss some implications of the Sun acquisition later in this chapter and some of the likely future directions Table 1-1 summarizes some of the important events and timing that led to the Oracle Exadata Database Machine.

vesicles along the sensory nerves to the ganglion, where it remains latent until activated, at which time it progresses down the axon to the skin Multiplication of the virus in epidermal cells causes swelling, vacuolization, and lysis of cell boundaries, leading to the formation of vesicles and so-called Lipschutz inclusion bodies Alternatively, the ganglia could be infected during the viremia of chickenpox, but then one would have to explain why only one or a few sensory ganglia become infected Reactivation of virus is attributed to waning immunity, which would explain the increasing incidence of zoster with aging and with lymphomas, administration of immunosuppressive drugs, AIDS, and radiation therapy The subject of pathogenesis of herpes zoster has been reviewed by Gilden and colleagues, and in a monograph by Rentier who describes the molecular and immune investigations pertaining to VZV Clinical Features As indicated above, the incidence of herpes zoster rises with age Hope-Simpson has estimated that if a cohort of 1000 people lived to 85 years of age, half would have had one attack of zoster and 10 would have had two attacks The notion that one attack of zoster provides lifelong immunity is incorrect, although recurrent attacks are rare and most repeated herpetic eruptions are due to HSV The sexes are equally affected, as is each side of the body Herpes zoster occurs in up to 10 percent of patients with lymphoma and 25 percent of patients with Hodgkin disease particularly in those who have undergone splenectomy or received radiotherapy Conversely, about 5 percent of patients who present with herpes zoster are found to have a concurrent malignancy (about twice the number that would be expected), and the proportion appears to be even higher if more than two adjacent dermatomes are involved The vesicular eruption is usually preceded for several days by itching, tingling, or burning sensations in the involved dermatome(s), and sometimes by malaise and fever as well Or there is severe localized or radicular pain that may be mistaken for pleurisy, appendicitis, cholecystitis, or, quite often, ruptured intervertebral disc, until the diagnosis is clari ed by the appearance of vesicles (nearly always within 72 to 96 h) The rash consists of clusters of tense clear vesicles on an erythematous base, which become cloudy after a few days (due to accumulation of in ammatory cells) and dry, crusted, and scaly after 5 to 10 days In a small number of patients, the vesicles are con uent and hemorrhagic, and healing is delayed for several weeks In most cases pain and dysesthesia last for 1 to 4 weeks; but in the others (7 to 33 percent in different series) the pain persists for months or, in different forms, even for years and presents a dif cult problem in management Impairment of super cial sensation in the affected dermatome(s) is common, and segmental weakness and atrophy are added in about 5 percent of patients In the majority of patients the rash and sensorimotor signs are limited to the territory of a single dermatome, but in some, particularly those with cranial or limb involvement, two or more contiguous dermatomes are involved Rarely (and usually in association with malignancy) the rash is generalized, like that of chickenpox, or altogether absent In half of the cases, the CSF shows a mild increase in cells, mainly lymphocytes, and a modest increase in protein content (although lumbar puncture is not required to establish the diagnosis) The diagnosis can be con rmed by direct immuno uorescence of a biopsied skin lesion, using antibody to VZV, or inferred by nding multinucleated giant cells in scrapings from the base of an early vesicle The spinal uid also contains antibodies to the virus or.

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